The world is moving so fast these days that the man who says it can't be done is generally interrupted by someone doing it.

Set the time after which the current quote is refreshed. Use a tool like Plash (MacOS) to set this page to your desktop's background. Tap the image to toggle unnecessary interface elements.

To load the site with the interface not showing, and with a certain refresh rate, set querystring parameters like so: https://andiquote.org/?showInterface=0&refreshDuration=300.