I have found it advisable not to give too much heed to what people say when I am trying to accomplish something of consequence. Invariably they proclaim it can't be done.

Set the time after which the current quote is refreshed. Use a tool like Plash (MacOS) to set this page to your desktop's background. Tap the image to toggle unnecessary interface elements.

To load the site with the interface not showing, and with a certain refresh rate, set querystring parameters like so: https://andiquote.org/?showInterface=0&refreshDuration=300.